PARADIGM SHIFT IN EARLY DIAGNOSIS
- Many cancers and other complex disease are detected late.
- Late detection results in increased morbidity and death
- Examples; liver, lung and gastric cancer
- Current biomarkers lack sensitivity and specificity to detect disease early.
- Available biomarkers and diagnostic methods are invasive; can’t be used for follow-up of healthy populations
- Not applicable for follow up of large “healthy” populations that are at risk