USD $49.00

epiSAMe is a nutritional supplement that promotes optimal hormone levels.

SAMe is a natural product in the human body, which can affect human health.

Our epiSAMe (S-adenosine Methionine) is a chemical compound found naturally in the body and is considered the most important methyl donor in the body.

What is epiSAMe?

The level of epiSAMe decreases as the body ages. Concomitantly, a number of health issues, including mood, joined, and liver disorders are likely to occur​.

All SAM-e molecules have two forms: the SS (active) isomer and the RS (inactive) isomer.

While epiSAMe comes in two stable salt forms; tosylate and butane disulphonate, only the tosylate form is backed by twenty years of research for safety and effectiveness.

biological age

Why Chose epiSAMe

In the Spotlight

The study done by University of California showed that SAM-e is as effective as Celecoxib, a prescription drug for Arthritis.

A Korean study found that SAM-e is as effective as the NSAID Nabumetone. 

The study from Massachusetts General Hospital demonstrated that SAM-e combined with antidepressants significantly increased remission rates in patients with major depression who failed conventional therapy

Arthritis Research UK study gives SAM-e the highest grade for oral supplement for osteoarthritis relief

Arthritis Today Magazine (October Issue) lists SAM-e as best supplement for osteoarthritis.


From the literature:

SAM-e has been shown to improve mood & emotional well being, joint health, comfort & mobility and healthy liver function in clinical studies.

In March of 2003, the AHRQ (Agency for Healthcare Research and Quality) a division of the United States Health and Human Services, released the findings of a major study on SAM-e.

SAM-e is as effective as conventional prescription medications in the treatment of depression.

SAM-e is as effective as standard prescription medications (NSAIDs) in the treatment of osteoarthritis.

SAM-e has significant benefits for patients suffering from various liver diseases. Natural SAM-e was not found to have any noticeable side effects.

Basic research on SAM-e on human cell lines and animals which were not yet followed by clinical studies

HKG Epitherapeutics

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